On September 16, sigma-Aldrich company rolls out CompoZr zinc to show nucleic acid is enzymatic (ZFN) reagent platform. Platform of CompoZr ZFN reagent aims to help investigator undertake to group of vivid cell gene target is mixed to fixed position accurate operation, have specific gene in order to form to delete, insert or the cellular department of repair or organism whole. Platform of CompoZr ZFN reagent is the form with custom-built service at first, development gives ZFN effect at specific target gene, will include finally to be based on the reagent box of ZFN, turn with what nod at forming eye scalar potential gene is inserted, and a series of merchandise on hand supply reagent, but action at the target gene that is studied extensively, gene is familial with access. Sigma this one brand-new the application related platform technology includes to build Knockout and Knock-in cell is, building albumen to convey the cell that the volume rises significantly is, and generation turns newly gene mode animal.

ZFN reagent is the DNA union albumen that a kind of classics transforms, they show in the user fixed position dot causes DNA double catenary to rupture, conduce to target has to gene group inside vivid cell to the editor. DNA double catenary ruptures exciting cell starts process of natural DNA repair, recombine with the source namely, be different from source extreme join, cause a dot particularity to recombine thereby. Use CompoZr reagent, investigator needs only fast, single step is operated, can undertake accurate target edits to gene group, get providing permanent, but genetic gene is deleted, the cell that insert and decorates is, this is unprecedented. In addition, sigma-Aldrich is cooperating with top learned man, be in in order to confirm ZFN is right bandicoot, small rat, the efficient sex of Knockout animal model is built in bunny and other species.

David Smoller of president of section of business of Sigma-Aldrich Research Biotech, the doctor says: "Zinc shows nucleic acid enzymatic technology has perspective more than 10 years extremely all the time, this technology is very at present mature already, enough changes people to have the kind of research to vivid cell and organism thoroughly. Sigma-Aldrich is in optimize ZFN production methods while, use us already some distribute ability, make the investigator of the whole world can use this exciting new technology. Make the investigator of the whole world can use this exciting new technology..

ZFNs conduces to build complete gene Knockout and Knock-in body cell, embryonic cell, former acting cell is, make investigator can more accurate thereby the biology function of appraisal gene. The gene group that ZFN interpose guides edits, hopeful is used at generation can be close to the ground newly to copy the disease animal model of human disease more, and for new remedy compound potential noxiousness provides more and real data. To biology pharmacy manufacturer, ZFN conduces to build have grow character is optimized, candy radical spends characteristic change, albumen crop carries the cell of advanced characteristic to fasten.
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